Searchable abstracts of presentations at key conferences in endocrinology
ea0011p272 | Diabetes, metabolism and cardiovascular | ECE2006
Effects of hyperglycemia on the AT1 receptor expression and secretory function in an INS-1E beta-cell line
Objectives: We have recently identified an islet renin-angiotensin system in the pancreas which was subjected to upregulation in an obesity-induced mouse model of Type 2 diabetes mellitus (T2DM). Blockade of the AT1 receptor (AT1R) activation in this diabetic model improves islet function. It is well known that hyperglycemia plays a pivotal role in beta-cell dysfunction and T2DM. Nevertheless, glucotoxicity-induced AT1R activation and its consequence in oxidative st...
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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